Research ethics approval: comprehensive mechanisms are essential but not available
نویسندگان
چکیده
منابع مشابه
Is Ethics Approval Necessary for all Trials? A Clear But Not Certain Process
All researchers want to do well planned study and their trial to be published and globally read. However, most of researchers feel there is generally a lack of guidance on how to prepare good papers and what the rules of ethics at the beginning of study. Thus, they seek to learn medical publication rules and find out the advices of the Helsinki Declaration which is prepared in line with WHO pol...
متن کاملNeed for ethics approval and patient consent in clinical research.
A key principle in clinical research is the need to obtain approval from a Research Ethics Committee before commencing a study, and then to obtain consent from each subject enrolled into the study. This tenet is highlighted in the Helsinki Declaration and reinforced in subsequent principles such as Good Clinical Practice/International Committee on Harmonisation. However, not all clinical studie...
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The generation of knockout mice with targeted gene disruption has provided a valuable tool for studying the immune response. Here we describe the use of CD4 and CD8 knockout mice to examine the role of CD4+ and CD8+ cells in initiating allotransplantation rejection. Pretreatment with a brief course of depletive anti-CD4 monoclonal antibody therapy allowed permanent survival of heart, but not sk...
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Sphingolipids (SLs) play critical roles in eukaryotic cells in the formation of lipid rafts, membrane trafficking, and signal transduction. Here we created a SL null mutant in the protozoan parasite Leishmania major through targeted deletion of the key de novo biosynthetic enzyme serine palmitoyltransferase subunit 2 (SPT2). Although SLs are typically essential, spt2- Leishmania were viable, ye...
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ژورنال
عنوان ژورنال: Family Practice
سال: 2007
ISSN: 0263-2136,1460-2229
DOI: 10.1093/fampra/cmm072